AGENDA
Board on Mathematical Sciences
Board on Life Sciences
National Research Council
Dynamical Modeling of Complex Biomedical Systems
Holiday Inn-Georgetown
2101 Wisconsin Ave., Washington, D.C.

April 26-28, 2001

Thursday, April 26

1:00-3:00 p.m. Overview Session -part 1

This session will introduce for the mathematical scientists some of the major developments taking place in the biomedical sciences, and also include a talk on the sort of data under development.

Two 30-minute talks followed by one hour of discussion.
1. Eduardo Marban (Johns Hopkins) Gene transfer/gene therapy
2. Terry Speed (Berkeley) Arrays
De Witt Sumners, (Florida State University) Moderator

3:00-3:30 Break

3:30-5:30 p.m. Mathematical Sciences and Disease States - part 1

Two 30-minute talks followed by one hour of discussion.
1. Charles Peskin (NYU), heart valve models
2. James Weiss (UCLA), arrhythmias
De Witt Sumners (Florida State University), moderator

5:30-6:30 p.m. Reception


Friday, April 27

8:00 a.m. Continental Breakfast

8:30-10:30 a.m. Overview Session - part 2

Two 30-minute talks followed by one hour of discussion.
1. Michael Phelps (UCLA), genetic engineering/molecular imaging/molecular drug
2. Douglas Lauffenburger (MIT), Cell Engineering: Quantitative Modeling and Experimental Studies of
How Cell Functions Depend on Molecular Properties
Jim Weiss (UCLA), moderator

10:30-11:00 a.m. Break

11:00-1:00 p.m. Mathematical Sciences and Disease States - part 2

Two 30-minute talks followed by one hour of discussion.
1. Dan Roden (Vanderbilt), pharmacogenetics
2. Bruce Levin (Emory University), Mathematical Models of the Population Dynamics of Antibiotic Therapy
Jim Weiss (UCLA), moderator

1:00 p.m. Lunch

2:00-5:30 p.m. Dynamical Models of Cellular Processes

Four 30-minute talks followed by 90 minutes of discussion.
1. John Tyson (Virginia Tech), The Eukaryotic Cell Cycle: Molecular Mechanisms and Mathematical Models
2. Byron Goldstein (Los Alamos), cell signaling
3. Garrett Odell (Univ. Washington)
4. George Oster (Berkeley)
Iain Johnstone (Stanford), moderator

5:30-6:30 p.m. Reception


Saturday, April 28

8:30 a.m. Continental Breakfast

9:00-12:30 p.m. Neuroscience

Four 30-minute talks followed by 90 minutes of discussion.
1. John Rinzel (NYU), Modeling the Thalamus in Sleep and Awake States
2. Don Johnson (Rice University), Information Processing: Data Analysis and Theory
3. Larry Abbott (Brandeis University)
4. Emery Brown (Massachusetts General Hospital), analysis of neural signals
Peter Bickel (Berkeley), moderator

12:30 p.m. Adjourn